Publications | mysite

Selected publications

2025

Neutrophil-specific targeting of STAT3 impairs tumor progression via the expansion of cytotoxic CD8+ T cells

Ozel I, Sha G, Bedzinska A, Pylaeva E, Antczak J, Thiel E, Anthony Squire A, Gunzer M, Zelinskyy G, Kurten C, Lang S, Kortylewski M, Granot Z, Jablonska J.

Signal Transduct Target Ther

β-Actin Deficiency in Baraitser-Winter Syndrome Type 1 Disrupts T-Cell Function and Immune Regulation: Implications for Targeted Therapy in Actinopathies

Bar-On Z, Reuven O, Lev A, Simon AJ, Salaymeh W, Shalom A, Somech R, Barel O, Porges S, Javasky E, Molho-Pessach V, Granot Z, Bijaoui D, Neuman T, Tal Y, Baniyash M, Berger M and Shamriz O.

J Clin Immunol

From Complexity to Consensus: A Roadmap For Neutrophil Classification

Ng LG, Ballesteros I, Cassatella MA, Egeblad M, Fridlender ZG, Gabrilovich D, Gao Q, Granot Z, Grieshaber-Bouyer R, Grimes HL, Hedrick CC, Hidalgo A, Kaplan MJ, Kubes P, Ling GS, Lu L, Hongbo RL, Mayadas TN, Moutsopoulos NM, Ng M, Nigrovic PA, Ostuni R, Pittet MJ, Quail DF, Silvestre-Roig C, Soehnlein O, Udalova IA, Xue R, Zhang N and Kwok I.

Immunity

2024

γδ T Cell-mediated Tumor Immunity is Tightly Regulated by STING and TGF-β Signaling Pathways

Luo J, Wang S, Yang Q, Fu Q, Zho C, LI T, Yang S, Zhao Y, Guo R, Ben X, Zheng Y, Li S, Yang G, Zhang H, Xioa H, Jiang Z, yan N, Kabelitz D, Sun G, Granot Z, Lu Ligong, You F, Hao J, Yin Z.

Adv Sci

Interactions between γδ T cells and neutrophils in cancer: Knowns and unknowns

Hao J. and Granot Z.

J Leukoc Biol

A Comprehensively Prognostic and Immunological Analysis of PARP11 in Pan-cancer

Wang S, Zhang M, Li T, Chen X, Wu Q, Tian D, Granot Z, Xu H, Hao J, Zhang H.

J Leukoc Biol

Hao & Granot 2024

2023

IRE1 endoribonuclease signaling promotes myeloid cell infiltration in glioblastoma

Obacz J, Archambeau J, Lafont E, Nivet M, Martin S, Aubry M, Voutetakis K, Pineau R, Boniface R, Sicari D, Pelizzari-Raymundo D, Ghukasyan G, McGrath E, Vlachavas EI, Le Gallo M, Le Reste PJ, Barroso K, Fainsod-Levi T, Obiedat A, Granot Z, Tirosh B, Samal J, Pandit A, Négroni L, Soriano N, Monnier A, Mosser J, Chatziioannou A, Quillien V, Chevet E, Avril T.

Neuro Oncol

Völs et al. 2022

Zelter et al. 2022

2022

Targeted nanoparticles modify neutrophil function in vivo

Völs S, Kaisar-Iluz N, Shaul ME, Ryvkin A, Ashkenazy H, Yehuda A, Atamneh R, Heinberg A, Ben-David-Naim M, Nadav M, Hirsch S, Mitesser V, Salpeter SJ, Dzikowski R, Hayouka Z, Gershoni JM, Fridlender ZG, Granot Z

Front. Immunol

Neutrophil phenotypes and functions in cancer: A consensus statement

Quail DF, Amulic B, Aziz M, Barnes BJ, Eruslanov E, Fridlender ZG, Goodridge HS, Granot Z, Hidalgo A, Huttenlocher A, Kaplan MJ, Malanchi I, Merghoub T, Meylan E, Mittal V, Pittet MJ, Rubio-Ponce A, Udalova IA, van den Berg TK, Wagner DD, Wang P, Zychlinsky A, de Visser KE, Egeblad M, Kubes P.

J. Exp. Med.

Neutrophils impose strong immune pressure against PfEMP1 variants implicated in cerebral malaria

Zelter T, Strahilevitz J, Simantov K, Yajuk O, Adams Y, Ramstedt Jensen A, Dzikowski R, Granot Z

EMBO Rep.

Recognition of Tumor Nidogen-1 by Neutrophil C-Type Lectin Receptors

Sionov RV, Lamanga C, Granot Z

Biomedicines

Radiation sparks a dark side in neutrophils

Heinberg A and Granot Z.

Nature Cancer

2021

The inhibitory receptor CD300a is essential for neutrophil mediated clearance of urinary tract infection in mice

Isaacson B, Baron M, Yamin R, Bachrach G, Levi-Schaffer F, Granot Z, Mandelboim O.

Eur J Immunol.

The PD-L1/PD-1 axis blocks neutrophil cytotoxicity in cancer

Yajuk O, Baron M, Toker S, Zelter T, Fainsod-Levi T and Granot Z.

Cells

Yajuk et al. 2021

2020

Interleukin-1α dependent survival of cardiac fibroblasts is associated with StAR/STARD1 expression and improved cardiac remodeling and function after myocardial infarction

Razin T, Melamed-Book N, Argaman J, Galin I, Lowy Y, Anuka E, Naftali-Shani N, Kandel-Kfir M, Garfinkel BP, Brielle S, Granot Z, Apte RN, Conway SJ, Molkentin JD, Kamari Y, Leor J, Orly J.

J Mol Cell Cardiol.

Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression

Parhi L, Alon-Maimon T, Sol A, Nejman D, Shhadeh A, Fainsod-Levi T, Yajuk O, Isaacson B, Abed J, Maalouf N, Nissan A, Sandbank J, Yehuda-Shnaidman E, Ponath F, Vogel J, Mandelboim O, Granot Z, Straussman R, Bachrach G.

Nat. Commun.

2019

Immature Low-Density Neutrophils Exhibit Metabolic Flexibility that Facilitates Breast Cancer Liver Metastasis

Hsu BE, Tabariès S, Johnson RM, Andrzejewski S, Senecal J, Lehuédé C, Annis MG, Ma EH, Völs S, Ramsay L, Froment R, Monast A, Watson IR, Granot Z, Jones RG, St-Pierre J, Siegel PM.

Cell Rep

Targeted siRNA Nanoparticles for Mammary Carcinoma Therapy

Ben-David-Naim M, Dagan A, Grad E, Aizik G, Nordling-David MM, Morss Clyne A, Granot Z, Golomb G.

Cancers (Basel)

Neutrophils as a Therapeutic Target in Cancer

Granot Z.

Frontiers in Immunology

Neutrophil Cathepsin G and Tumor Cell RAGE Facilitate Neutrophil Anti-Tumor Cytotoxicity

Sionov RV, Fainsod-Levi T, Zelter T, Polyansky L, Pham CT and Granot Z.

Oncoimmunology

TRPM2 modulates neutrophil attraction to murine tumor cells by regulating CXCL2 expression

Gershkovitz M, Fainsod-Levi T, Zelter T, Sionov RV and Granot Z.

Cancer Immunology Immunotherapy

Sionov et al. 2019

Granot 2019

2018

Microenvironmental cues determine tumor cell susceptibility to neutrophil cytotoxicity

Gershkovitz M, Fainsod-Levi T, Khawaled S, Shaul ME, Sionov RV, Cohen-Daniel L, Aqeilan RI, Shaul YD, Fridlender ZG and Granot Z.

Cancer Research

TRPM2 mediates neutrophil killing of disseminated tumor cells

Gershkovitz M, Caspi Y, Fainsod-Levi T, Katz B, Michaeli J, Khawaled S, Lev S, Polyansky L, Shaul ME, Sionov RV, Cohen-Daniel L, Aqeilan RI, Shaul YD, Mori Y, Karni R, Fridlender ZG, Binshtok AM and Granot Z.

Cancer Research