Welcome to the Granot Lab
Neutrophils and Cancer Research
Selected Publications
“The joy of discovery is certainly the liveliest that the mind of man can ever feel”
- Claude Bernard -
2022
Targeted nanoparticles modify neutrophil function in vivo
Völs S, Kaisar-Iluz N, Shaul ME, Ryvkin A, Ashkenazy H, Yehuda A, Atamneh R, Heinberg A, Ben-David-Naim M, Nadav M, Hirsch S, Mitesser V, Salpeter SJ, Dzikowski R, Hayouka Z, Gershoni JM, Fridlender ZG, Granot Z
Front. Immunol
Neutrophil phenotypes and functions in cancer: A consensus statement
Quail DF, Amulic B, Aziz M, Barnes BJ, Eruslanov E, Fridlender ZG, Goodridge HS, Granot Z, Hidalgo A, Huttenlocher A, Kaplan MJ, Malanchi I, Merghoub T, Meylan E, Mittal V, Pittet MJ, Rubio-Ponce A, Udalova IA, van den Berg TK, Wagner DD, Wang P, Zychlinsky A, de Visser KE, Egeblad M, Kubes P.
J. Exp. Med.
Recognition of Tumor Nidogen-1 by Neutrophil C-Type Lectin Receptors
Sionov RV, Lamanga C, Granot Z
Biomedicines
Neutrophils impose strong immune pressure against PfEMP1 variants implicated in cerebral malaria
Zelter T, Strahilevitz J, Simantov K, Yajuk O, Adams Y, Ramstedt Jensen A, Dzikowski R, Granot Z
EMBO Rep.
2021
The inhibitory receptor CD300a is essential for neutrophil mediated clearance of urinary tract infection in mice
Isaacson B, Baron M, Yamin R, Bachrach G, Levi-Schaffer F, Granot Z, Mandelboim O.
Eur J Immunol.
The PD-L1/PD-1 axis blocks neutrophil cytotoxicity in cancer
Yajuk O, Baron M, Toker S, Zelter T, Fainsod-Levi T and Granot Z.
Cells
2020
Razin T, Melamed-Book N, Argaman J, Galin I, Lowy Y, Anuka E, Naftali-Shani N, Kandel-Kfir M, Garfinkel BP, Brielle S, Granot Z, Apte RN, Conway SJ, Molkentin JD, Kamari Y, Leor J, Orly J.
J Mol Cell Cardiol.
Parhi L, Alon-Maimon T, Sol A, Nejman D, Shhadeh A, Fainsod-Levi T, Yajuk O, Isaacson B, Abed J, Maalouf N, Nissan A, Sandbank J, Yehuda-Shnaidman E, Ponath F, Vogel J, Mandelboim O, Granot Z, Straussman R, Bachrach G.
Nat. Commun.
2019
Hsu BE, Tabariès S, Johnson RM, Andrzejewski S, Senecal J, Lehuédé C, Annis MG, Ma EH, Völs S, Ramsay L, Froment R, Monast A, Watson IR, Granot Z, Jones RG, St-Pierre J, Siegel PM.
Cell Rep
Targeted siRNA Nanoparticles for Mammary Carcinoma Therapy
Ben-David-Naim M, Dagan A, Grad E, Aizik G, Nordling-David MM, Morss Clyne A, Granot Z, Golomb G.
Cancers (Basel)
Neutrophil Cathepsin G and Tumor Cell RAGE Facilitate Neutrophil Anti-Tumor Cytotoxicity
Sionov RV, Fainsod-Levi T, Zelter T, Polyansky L, Pham CT and Granot Z.
Oncoimmunology
TRPM2 modulates neutrophil attraction to murine tumor cells by regulating CXCL2 expression
Gershkovitz M, Fainsod-Levi T, Zelter T, Sionov RV and Granot Z.
Cancer Immunology Immunotherapy
2018
Microenvironmental cues determine tumor cell susceptibility to neutrophil cytotoxicity
Gershkovitz M, Fainsod-Levi T, Khawaled S, Shaul ME, Sionov RV, Cohen-Daniel L, Aqeilan RI, Shaul YD, Fridlender ZG and Granot Z.
Cancer Research
TRPM2 mediates neutrophil killing of disseminated tumor cells
Gershkovitz M, Caspi Y, Fainsod-Levi T, Katz B, Michaeli J, Khawaled S, Lev S, Polyansky L, Shaul ME, Sionov RV, Cohen-Daniel L, Aqeilan RI, Shaul YD, Mori Y, Karni R, Fridlender ZG, Binshtok AM and Granot Z.
Cancer Research
2017
The regulation of pre-metastatic niche formation by neutrophils
Jablonska J, Lang S, Sionov RV and Granot Z.
Oncotarget
Michaeli J, Shaul ME, Mishalian I, Hovav AH, Levy L, Zolotriov L, Granot Z and Fridlender ZG.
Oncoimmunology
Stromal Cell-Derived Factor 1 Mediates Immune Cell Attraction upon Urinary Tract Infection.
Isaacson B, Hadad T, Glasner A, Gur C, Granot Z, Bachrach G and Mandelboim O.
Cell Rep.
Always Look On the Bright Side: Anti-Tumor Functions of Neutrophils.
Völs S, Sionov RV and Granot Z.
Curr Pharm Des
The diversity of circulating neutrophils in cancer.
Mishalian I, Granot Z and Fridlender ZG.
Immunobiology
2016
Rahat MA, Coffelt SB, Granot Z, Muthana M and Amedei A.
Mediators Inflamm
Isolation and Characterization of Low- vs. High-Density Neutrophils in Cancer.
Sagiv JY, Völs S and Granot Z.
Methods Mol Biol.
2015
The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment
RV Sionov, ZG Fridlender and Z Granot
Cancer Microenvironment
Promoting metastasis: neutrophils and T cells join forces.
Fridlender ZG, Albelda SM and Granot Z.
Cell Res.
Isolation and Characterization of Neutrophils with Anti-Tumor Properties.
Sionov RV, Assi S, Gershkovitz M, Sagiv JY, Polyansky L, Mishalian I, Fridlender ZG and Granot Z.
J Vis Exp.
The rejuvenating effect of pregnancy on muscle regeneration.
Falick Michaeli T, Laufer N, Sagiv JY, Dreazen A, Granot Z, Pikarsky E, Bergman Y and Gielchinsky Y.
Aging Cell
2014
Int J Cancer
2013
Cell Host Microbe