Selected Publications

“The joy of discovery is certainly the liveliest that the mind of man can ever feel”

- Claude Bernard -

2022

Targeted nanoparticles modify neutrophil function in vivo

Völs S, Kaisar-Iluz N, Shaul ME, Ryvkin A, Ashkenazy H, Yehuda A, Atamneh R, Heinberg A, Ben-David-Naim M, Nadav M, Hirsch S, Mitesser V, Salpeter SJ, Dzikowski R, Hayouka Z, Gershoni JM, Fridlender ZG, Granot Z

Front. Immunol

Neutrophil phenotypes and functions in cancer: A consensus statement

Quail DF, Amulic B, Aziz M, Barnes BJ, Eruslanov E, Fridlender ZG, Goodridge HS, Granot Z, Hidalgo A, Huttenlocher A, Kaplan MJ, Malanchi I, Merghoub T, Meylan E, Mittal V, Pittet MJ, Rubio-Ponce A, Udalova IA, van den Berg TK, Wagner DD, Wang P, Zychlinsky A, de Visser KE, Egeblad M, Kubes P.

J. Exp. Med.

Recognition of Tumor Nidogen-1 by Neutrophil C-Type Lectin Receptors

Sionov RV, Lamanga C, Granot Z

Biomedicines

Neutrophils impose strong immune pressure against PfEMP1 variants implicated in cerebral malaria

Zelter T, Strahilevitz J, Simantov K, Yajuk O, Adams Y, Ramstedt Jensen A, Dzikowski R, Granot Z

EMBO Rep.

Radiation sparks a dark side in neutrophils

Heinberg A and Granot Z.

Nature Cancer

2021

The inhibitory receptor CD300a is essential for neutrophil mediated clearance of urinary tract infection in mice

Isaacson B, Baron M, Yamin R, Bachrach G, Levi-Schaffer F, Granot Z, Mandelboim O.

Eur J Immunol.

The PD-L1/PD-1 axis blocks neutrophil cytotoxicity in cancer

Yajuk O, Baron M, Toker S, Zelter T, Fainsod-Levi T and Granot Z.

Cells

2020

Interleukin-1α dependent survival of cardiac fibroblasts is associated with StAR/STARD1 expression and improved cardiac remodeling and function after myocardial infarction

Razin T, Melamed-Book N, Argaman J, Galin I, Lowy Y, Anuka E, Naftali-Shani N, Kandel-Kfir M, Garfinkel BP, Brielle S, Granot Z, Apte RN, Conway SJ, Molkentin JD, Kamari Y, Leor J, Orly J.

J Mol Cell Cardiol.

Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression

Parhi L, Alon-Maimon T, Sol A, Nejman D, Shhadeh A, Fainsod-Levi T, Yajuk O, Isaacson B, Abed J, Maalouf N, Nissan A, Sandbank J, Yehuda-Shnaidman E, Ponath F, Vogel J, Mandelboim O, Granot Z, Straussman R, Bachrach G.

Nat. Commun.

2019

Immature Low-Density Neutrophils Exhibit Metabolic Flexibility that Facilitates Breast Cancer Liver Metastasis

Hsu BE, Tabariès S, Johnson RM, Andrzejewski S, Senecal J, Lehuédé C, Annis MG, Ma EH, Völs S, Ramsay L, Froment R, Monast A, Watson IR, Granot Z, Jones RG, St-Pierre J, Siegel PM.

Cell Rep

Targeted siRNA Nanoparticles for Mammary Carcinoma Therapy

Ben-David-Naim M, Dagan A, Grad E, Aizik G, Nordling-David MM, Morss Clyne A, Granot Z, Golomb G.

Cancers (Basel)

Neutrophils as a Therapeutic Target in Cancer

Granot Z.

Frontiers in Immunology

Neutrophil Cathepsin G and Tumor Cell RAGE Facilitate Neutrophil Anti-Tumor Cytotoxicity

Sionov RV, Fainsod-Levi T, Zelter T, Polyansky L, Pham CT and Granot Z.

Oncoimmunology

TRPM2 modulates neutrophil attraction to murine tumor cells by regulating CXCL2 expression

Gershkovitz M, Fainsod-Levi T, Zelter T, Sionov RV and Granot Z.

Cancer Immunology Immunotherapy

2018

Microenvironmental cues determine tumor cell susceptibility to neutrophil cytotoxicity

Gershkovitz M, Fainsod-Levi T, Khawaled S, Shaul ME, Sionov RV, Cohen-Daniel L, Aqeilan RI, Shaul YD, Fridlender ZG and Granot Z.

Cancer Research

TRPM2 mediates neutrophil killing of disseminated tumor cells

Gershkovitz M, Caspi Y, Fainsod-Levi T, Katz B, Michaeli J, Khawaled S, Lev S, Polyansky L, Shaul ME, Sionov RV, Cohen-Daniel L, Aqeilan RI, Shaul YD, Mori Y, Karni R, Fridlender ZG, Binshtok AM and Granot Z.

Cancer Research